Mutant Actinosynnema pretiosum strain with increased maytansinoid production

   
   

A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and capable of growth under varied culture conditions, and methods of producing maytansinoid ansamitocins by culturing PF4-4 in a suitable growth medium.

Un micro-organisme qui est une contrainte bactérienne de mutant du pretiosum d'Actinosynnema d'espèces, indiqué PF4-4, (atcc PTA-3921), étant capable de produire des ansamitocins de maytansinoid tels que l'ansamitocin P-3 dans le rendement amélioré a comparé aux contraintes connues précédentes, et capable de la croissance dans des conditions diverses de culture, et des méthodes de produire des ansamitocins de maytansinoid en cultivant PF4-4 dans un milieu approprié de croissance.

 
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