Scyphostatin analogues as SMase inhibitors

   
   

The present invention relates to novel scyphostatin analogues, which distinguish themselves by acting as SMase inhibitors so that they are of therapeutic use for a number of diseases such as a HIV infection, neurodegenerative diseases, inflammatory diseases, apoplexy, ischemia, myocardial infarction or in the case of atherosclerosis.

De onderhavige uitvinding heeft op nieuwe scyphostatinanalogons betrekking, die zich door als inhibitors onderscheiden te handelen SMase zodat zij van therapeutisch gebruik voor een aantal ziekten zoals een HIV besmetting, neurodegenerative ziekten, ontstekingsziekten, apoplexie, ischemie, myocardiaal infarct of in het geval van atherosclerose zijn.

 
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