Agents for treating pain, methods for producing the agents and methods for
treating pain by administration to a patient of a therapeutically
effective amount of the agent are disclosed. The agent may include a
clostridial neurotoxin, a fragment or a derivative thereof, attached to a
targeting component, wherein the targeting component is selected from a
group consisting of compounds which selectively binds at the alpha-2B or
alpha-2B/alpha-2C adrenergic receptor subtype(s) as compared to other
binding sites, for example, the alpha-2A adrenergic receptor subtype.
