Cytochrome P450 oxygenases and their uses

   
   

Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxol.TM.), related taxoids, as well as intermediates in the Taxol biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the oxygenase enzymes.

Показаны энзимы оксигеназы и польза таких энзимов произвести paclitaxel (Taxol.TM.), родственные taxoids, так же, как промежуточные звена в pathway Taxol биосинтетическом. Также показаны последовательности нуклеиновой кислоты шифруя энзимы оксигеназы.

 
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< Method for the selective removal of acyl-functionality attached to the 2'-hydroxy-group of paclitaxel-related derivatives

< Semi-synthesis of a protected baccatin III compound

> Mass production of paclitaxel by changing the temperature of the medium during the plant cell culture

> Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities

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