A compound, or a solvate or a salt thereof, of formula (I):
##STR1##
wherein, Ar is an optionally substituted aryl or a C.sub.5-7 cycloalkdienyl
group, or an optionally substituted C.sub.5-7 cycloalkyl group, or an
optionally substituted single or fused ring aromatic heterocyclic group;
R is hydrogen, linear or branched C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl,
C.sub.3-7 cycloalkylalkyl;
R.sub.1 represents hydrogen or up to three optional substituents selected
from the list consisting of: C.sub.1-6 alkyl, C.sub.1-6 alkenyl, aryl,
C.sub.1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido,
sulphonamido, C.sub.1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, amino or
mono- and di-C.sub.1-6 alkylamino,
R.sub.2 represents a moiety --(CH.sub.2).sub.n --NYY.sub.2 wherein n is an
integer in the range of from 1 to 9, Y.sub.1 and Y.sub.2 are independently
selected from C.sub.1-6 -alkyl; C.sub.1-6 alkyl substituted with hydroxy,
alkoxy, C.sub.1-6 alkylamino or bis (C.sub.1-6 alkyl) amino; C3-6
cycloalkyl; C4-6 azacycloalkyl; C.sub.1-6 -alkenyl; aryl or aryl-C.sub.1-6
-alkyl or Y.sub.1 and Y.sub.2 together with the nitrogen atom to which
they are attached represent an optionally substituted N-linked single or
fused ring heterocyclic group;
R.sub.3 is branched or linear C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl,
C.sub.4-7 cycloalkylalkyl, optionally substituted aryl, or an optionally
substituted single or fused ring aromatic heterocyclic group; and R.sub.4
represents hydrogen or C.sub.1-6 alkyl, R.sub.5 represents hydrogen or
halogen; a process for preparing such compounds, a pharmaceutical
composition comprising such compounds and the use of such compounds and
composition in medicine.
