A novel class of compounds, i.e., 1,1-bis-H-phosphinates (or
1,1-bis-H-phosphinic acid derivatives) are provided. Also provided are
novel methods for producing 1,1-bis-H-phosphinates and
1,1-bis-H-phosphinate conjugates. These compounds and conjugates are used
are precursors of bisphosphonates and bisphosphonate conjugates,
respectively, or as prodrugs directly for treating bone-related and
various other diseases.
