Human ABC1 promoter and assays based thereon

   
   

Disclosed is the sequence of the human ABC1 promoter, a method for expressing foreign DNA in host cells using the human ABC1 promoter, including a method of determining whether a chemical not previously known to be a modulator of the human ABC1 gene transcriptionally modulates the expression of the human ABC1 gene. Also disclosed is a sterol-responsive region of the human ABC1 promoter, along with a showing that it is activated by hydroxysterols and 9-cis-retinoic acid, implicating a mechanism of activation involving LXR/RXR heterodimers.

 
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