Tricyclic compounds and uses thereof

   
   

Substituted isoquinolines, isochromanones and isothiochromanones that inhibit the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6) and/or the enzyme cyclooxygenase-2 (COX-2) and/or interleukin-10 (IL-10). Compositions containing such compounds and methods of using such compounds for treatment and/or prevention of inflammation, inflammatory diseases, immunologic diseases and other diseases mediated by TNF-alpha, IL-6, COX-2 and/or IL-10 are also disclosed.

Ersetzte isoquinolines, isochromanones und isothiochromanones, die das Pro-entzündliche cytokines Tumor-Nekrose Faktor-Alpha (TNF-Alpha) und/oder interleukin-6 (IL-6) und/oder das Enzym cyclooxygenase-2 (COX-2) und/oder interleukin-10 (IL-10) hemmen. Der Aufbau, der solche Mittel und Methoden des Verwendens solcher Mittel für Behandlung enthalten und/oder die Verhinderung der Entzündung, der entzündlichen Krankheiten, der immunologischen Krankheiten und anderen der Krankheiten, die durch TNF-Alpha, IL-6, COX-2 und/oder IL-10 vermittelt werden, werden auch freigegeben.

 
Web www.patentalert.com

< Methods of inhibiting osteoclastogenesis

< N-substituted-N'-substituted urea derivatives and pharmaceutical compositions containing the derivatives

> Polynucleotides encoding neutrokine-.alpha.

> Toso

~ 00124