Death domain containing receptors

   
   

The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

 
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< Apo-2 ligand

< Antibody delivery system for biological response modifiers

> IL-1/TNF--activated kinase (ITAK), and methods of making and using the same

> Heterologous polypeptide of the TNF family

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