The present invention covers radiosensitizers containing as an active
ingredient halogenated derivatives of boronated porphyrins containing
multiple carborane cages having the structure
##STR1##
which selectively accumulate in neoplastic tissue within the irradiation
volume and thus can be used in cancer therapies including, but not limited
to, boron neutron--capture therapy and photodynamic therapy. The present
invention also covers methods for using these radiosensitizers in tumor
imaging and cancer treatment.
A invenção atual cobre os radiosensitizers que contêm como um ingrediente ativo halogenated derivatives de boronated os porphyrins que contêm as gaiolas múltiplas do carborane que têm o ## do ## STR1 da estrutura que acumule seletivamente no tecido neoplastic dentro do volume do irradiation e assim possa ser usado em terapias do cancer including, mas não limitado a, nêutron do boro -- capture a terapia e a terapia photodynamic. A invenção atual cobre também métodos para usar estes radiosensitizers na imagem latente do tumor e no tratamento do cancer.
