Gamma-secretase inhibitors

   
   

Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are di-astereoisomers of known protease inhibitors. ##STR1##

Gli inibitori di gamma-secretase-secretase, utili nel trattamento o nella prevenzione della malattia del Alzheimer, sono rilevati. I residui preferiti hanno, come la parte centrale della molecola, la struttura (a) e sono Di-astereoisomers degli inibitori conosciuti della proteasi. ## del ## STR1

 
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< Endothelin converting enzymes and the amyloid .beta. peptide

< Prevention and treatment of amyloidogenic disease

> Extended tethering approach for rapid identification of ligands

> Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder

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