Polypeptides are expressed by the pituitary-tumor-transforming-gene (PTTG),
formerly known as pituitary-tumor-specific-gene (PTSG), and nucleic acids
encode them. Examples are the human and rat PTTG proteins. The nucleic
acids may be applied to the production of a recombinant protein, and to
the detection of the presence of PTTG genes in different species. The
nucleic acids may be operatively linked to a vector, optionally provided
with control and expression sequences and/or being carried by a host cell.
The nucleic acids may also be delivered to a mammal to compensate for the
absence, or a defective expression, of endogenous protein. The nucleic
acids, proteins, and antibodies are also employed in disgnostic assays, as
well as, for example, in the production of anti-PTTG antibodies (protein),
therapeutic compositions and other applications of the proteins and
antibodies. Various kits utilize nucleic acids, polypeptides, and/or
antibodies. A transgenic non-human mammal expresses PTTG.
