Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade

   
   

The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

L'invenzione riguarda l'arile policiclico sostituito ed il pyrimidinone di heteroaryl compone utile mentre gli inibitori delle proteasi della serina della coagulazione procedono in sequenza e residui, composizioni e metodi per la terapia dell'anticoagulante per il trattamento e la prevenzione di una varietà di termini thrombotic compreso l'arteria coronaria e le malattie cerebrovascolari.

 
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