Methods for the identification of fungal glucose utilization inhibitors and antifungal agents

   
   

The present invention provides methods for simultaneously assessing microbial phosphoglucose isomerase, ketol-isomerase and glucosamine-6-phosphate acetyltransferase activities, by measuring the production of Coenzyme A (CoA). The present invention finds use in the isolation of new classes of antifungal drugs, wherein the compounds have the ability to inhibit fungal glucose utilization.

Die anwesende Erfindung stellt Methoden für Mikrobenphosphoglucose Isomerase-, Ketolisomerase- und glucosamine-6-phosphate Acetyltransferasetätigkeiten gleichzeitig festsetzen, vom Messen der Produktion Coenzyms A zur Verfügung (CoA). Der anwesende Erfindungentdeckunggebrauch in der Lokalisierung der neuen Kategorien der pilzbefallverhütenden Drogen, worin die Mittel die Fähigkeit haben, pilzartige Glukoseanwendung zu hemmen.

 
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