The invention relates to substituted polycyclic aryl and heteroaryl
tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl
ester transfer protein (CETP; plasma lipid transfer protein-I) and
compounds, compositions and methods for treating atherosclerosis and other
coronary artery diseases. Preferred tertiary-heteroalkylamine compounds
are substituted N-fused-phenyl-N-benzyl aminoalcohols. A preferred
specific N-fused-phenyl-N-benzyl aminoalcohol is the compound:
##STR1##
A invenção relaciona-se aos compostos tertiary-heteroalkylamine-heteroalkylamine polycyclic substituídos do arilo e do heteroaryl úteis enquanto os inibidores do ester do cholesteryl transferem a proteína (CETP; proteína-Eu de transferência do lipid do plasma) e compostos, composições e métodos para tratar o atherosclerosis e as outras doenças de artery coronary. Os compostos tertiary-heteroalkylamine-heteroalkylamine preferidos são aminoalcohols N-fund-phenyl-N-n-fused-phenyl-N-benzyl substituídos. Um aminoalcohol N-fund-phenyl-N-n-fused-phenyl-N-benzyl específico preferido é o composto: ## do ## STR1
