Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility

   
   

A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.

Uma classe da novela dos compostos sabidos como ácidos nucleic do peptide, liga costas complementares do DNA e do RNA, e fá-las geralmente assim mais fortemente do que as costas correspondentes do DNA ou do RNA ao exibir o specificity e o solubility aumentados da seqüência. Os ácidos nucleic do peptide compreendem os ligands selecionados de um grupo que consiste em nucleobases naturais e em nucleobases non-natural-ocorrendo, including 2,6-diaminopurine, unido a uma espinha dorsal do polyamide, e contêm correntes laterais do amine alkyl.

 
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