Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods

   
   

This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

Esta invenção relaciona-se às proteínas (por exemplo, peptides) que é capaz de facilitar o transporte de um agente ativo através de um tecido gastro-intestinal humano ou animal, e os derivatives (por exemplo, fragmentos) e os analogs disso, e o nucleotide arranja em seqüência o coding para proteínas e derivatives ditos. As proteínas da invenção têm o uso em facilitar o transporte de agentes ativos do lado do lumenal do GIT no sistema systemic do sangue, e/ou em alvejar agentes ativos ao GIT. Assim, para o exemplo, ligando (covalently ou noncovalently) uma proteína da invenção a uma droga oral administrada, a droga pode ser alvejada aos locais específicos do receptor ou aos pathways do transporte que são conhecidos para se operar no intervalo gastrointestinal humano, assim facilitando seu absorption no sistema systemic.

 
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