Alzheimer's disease secretase, APP substrates therefor, and uses therefor

   
   

The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.

De onderhavige uitvinding verstrekt het enzym en de enzymatische procedures om de het splijtenplaats van beta. secretase van de APP proteïne te splijten en de bijbehorende nucleic zuren, peptides, de vectoren, de cellen en de cel isoleren en analyses. De uitvinding verstrekt verder gewijzigde APP eiwit en bijbehorende nucleic zuren, peptides, vectoren, cellen, en de cel isoleert, en analyses die bijzonder nuttig zijn om kandidaattherapeutiek voor behandeling of preventie van de ziekte van Alzheimer te identificeren.

 
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