Proteins within the type E botulinum neurotoxin complex

   
   

The invention features a polypeptide complex synthesized by bacteria of the genus Clostridia that contains the serotype E botulinum neurotoxin and five neurotoxin associated polypeptides having molecular weights of about 118, 80, 65, 40, and 18 kDa, respectively. The complex is useful in the treatment of diseases or conditions that are caused by excessive release of acetylcholine from presynaptic nerve terminals.

L'invenzione caratterizza un complesso del polipeptide sintetizzato rispettivamente dai batteri del genere clostridi che contiene la neurotossina botulina del sierotipo E e cinque polipeptidi associati neurotossina che hanno pesi molecolari del circa kDa 118, 80, 65, 40 e 18. Il complesso รจ utile nel trattamento delle malattie o delle circostanze che sono causate dal rilascio eccessivo di acetilcolina dai terminali presinaptici del nervo.

 
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