Nanomachines fueled by nucleic acid strand exchange

   
   

The rate of nucleic acid strand exchange can be greatly enhanced if one of the strands of a double-stranded nucleic acid oligomer has a single-stranded extension, or "toehold," to which a complementary, single-stranded, nucleic acid oligomer can bind. Toehold-facilitated strand exchange makes possible the controlled addition and removal of one nucleic acid strand from a second, complementary strand. Oligomers are designed and used to carry out controlled, repetitive nucleic acid structural transitions mediated by hybridization and toehold-facilitated strand exchange reactions, which in turn control the operation of a nanomachine or a 2-state molecular switch.

El índice del intercambio del filamento del ácido nucleic puede ser realzado grandemente si uno de los filamentos de un oligomer double-stranded del ácido nucleic tiene una extensión solo-trenzada, o "toehold," a cuál puede atar un oligomer del ácido complementario, solo-trenzado, nucleic. el intercambio Toehold-facilitado del filamento hace posible la adición y el retiro controlados de un filamento de un segundo, filamento complementario del ácido nucleic. Se diseñan los oligomers y utilizado realizar las transiciones estructurales controladas, repetidoras del ácido nucleic mediadas por el hibridación y el filamento toehold-facilitado intercambie las reacciones, que alternadamente controlan la operación de un nanomachine o de un interruptor molecular 2-state.

 
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