Methods for vaccination and vaccines therefor

   
   

The invention relates to methods of and compositions for vaccinating a mammal against a disease, wherein a mixture is administered which includes (i) a nucleic acid which encodes a first epitope and (ii) a peptide containing a second epitope such that both of the nucleic acid and the second epitope are taken up by and the nucleic acid is expressed in a professional antigen presenting cell of the mammal, and the first and second epitopes are processed in the cell such that an immune response is elicited in the mammal to the epitopes.

La invención se relaciona con los métodos de y las composiciones para vacunar un mamífero contra una enfermedad, en donde se administra una mezcla que incluye (i) un ácido nucleic que codifique un primer epitope y (ii) un peptide que contiene un segundo epitope tales que ambos el ácido nucleic y segundo epitope están tomados cerca y el ácido nucleic está expresado en un antígeno profesional que presenta la célula del mamífero, y los primeros y segundos epitopes se procesan en la célula tales que una inmunorespuesta está sacada en el mamífero a los epitopes.

 
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