Methods for reducing flushing in individuals being treated for hyperlipidemia with nicotinic acid are disclosed. According to the methods of the present invention, flushing can be reduced in individuals under going nicotinic acid therapy without causing drug-induced hepatotoxicity to a level that would require the nicotinic acid therapy to be discontinued by orally administering to the individuals intermediate nicotinic acid formualtions having unique biopharmaceutical characteristics as a single dose once per day. While the methods of the present invention contemplate administering the intermediate release nicotinic acid formulations at any time during a 24 hour period, it is preferable to administer them once-a-day as a single dose during the evening or at night between about 6:00 pm. and 12:00 a.m., preferably between about 8:00 p.m. and 12:00 a.m., and most preferably between about 8:00 p.m. and 10:00 p.m.

Os métodos para reduzir nivelar nos indivíduos que estão sendo tratados para o hyperlipidemia com o ácido nicotinic são divulgados. De acordo com os métodos da invenção atual, nivelar pode ser reduzido nos indivíduos sob a terapia indo do ácido nicotinic sem causar o hepatotoxicity droga-induzido a um nível que requeira a terapia do ácido nicotinic ser interrompido oral administrando aos formualtions intermediários do ácido nicotinic dos indivíduos que têm características biopharmaceutical originais como um único dose uma vez por o dia. Quando os métodos da invenção atual contemplam administrar os formulations intermediários do ácido nicotinic da liberação em em qualquer altura que durante uns 24 períodos da hora, é preferível administrá-los uma vez que-um-dia como um único dose durante a noite ou na noite entre aproximadamente 6:00 pm. e 12:00 a.m., preferivelmente entre aproximadamente 8:00 p.m. e 12:00 a.m., e o mais preferivelmente entre aproximadamente 8:00 p.m. e 10:00 p.m.

 
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