The present invention reveals a class of novel inhibitors of metalloproteinase. For convenience, these polypeptides are referred to as "TIMP-3", as these polypeptides represent a new class of members of the tissue inhibitors of metalloproteinases. Also provided are DNA sequences coding for all or part of the TIMP-3s, vectors containing such DNA sequences, and host cells transformed or transfected with such vectors. In addition, methods of producing recombinant TIMP-3s, methods of treating disorders, pharmaceutical compositions including TIMP-3s and antibodies selectively binding TIMP-3s are provided.

A invenção atual revela uma classe de inibidores da novela do metalloproteinase. Para a conveniência, estes polypeptides são consultados a como "TIMP-3", porque estes polypeptides representam uma classe nova dos membros dos inibidores do tecido dos metalloproteinases. São fornecidas também as seqüências do DNA que codificam para o todo ou uma parte do TIMP-3s, dos vetores que contêm tais seqüências do DNA, e das pilhas de anfitrião transformadas ou transfected com tais vetores. Além, os métodos de produzir TIMP-3s recombinant, os métodos de tratar disorders, as composições pharmaceutical including TIMP-3s e os antibodies que ligam seletivamente TIMP-3s são fornecidos.

 
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