The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted mercapto amines. A preferred specific N,N-disubstituted mercapto amine is the compound: ##STR1##

A invenção relaciona-se aos compostos tertiary-heteroalkylamine-heteroalkylamine polycyclic substituídos do arilo e do heteroaryl úteis enquanto os inibidores do ester do cholesteryl transferem a proteína (CETP; proteína-Eu de transferência do lipid do plasma) e compostos, composições e métodos para tratar o atherosclerosis e as outras doenças de artery coronary. Os compostos tertiary-heteroalkylamine-heteroalkylamine preferidos são N substituído, amines N-n-disubstituted do mercapto. Um N específico preferido, amine N-n-disubstituted do mercapto é o composto: ## do ## STR1