Compounds and methods for the diagnosis and treatment of Ehrlichia
infection, inparticular human granulocytic ehrlichiosis, are disclosed.
The compounds provided include polypeptides that contain at least one
antigenic portion of an Ehrlichia antigen and DNA sequences encoding such
polypeptides. Pharmaceutical compositions and vaccines comprising such
polypeptides or DNA sequences are also provided. Diagnostic kits
containingsuch polypeptides or DNA sequences and a suitable detection
reagent may be used for the detection of Ehrlichia infection in patients
and biological samples. Antibodies directed against such polypeptides are
also provided.