The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth phospholipase A.sub.2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

A invenção atual relaciona-se às proteínas parasíticas do helminth PLA2; às moléculas parasíticas do ácido nucleic do helminth PLA2, including aqueles que codificam tais proteínas; aos antibodies levantados de encontro a tais proteínas; e aos compostos que inibem a atividade parasítica do phospholipase A.sub.2 do helminth. A invenção atual inclui também métodos para obter tais proteínas, moléculas do ácido nucleic, antibodies, e inibidores. São incluídas também na invenção atual as composições therapeutic que compreendem tais proteínas, moléculas do ácido nucleic, antibodies, e/ou inibidores as.well.as o uso de tais composições therapeutic proteger animais das doenças causadas por helminths parasíticos.

 
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> Polymers for delivering nitric oxide in vivo

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