The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

A invenção atual relaciona-se aos compostos do sulfoxide e do bis-bis-sulfoxide da novela, às composições que compreendem compostos do sulfoxide e do bis-bis-sulfoxide, e aos métodos úteis para tratar e impedir doenças cardiovascular, dyslipidemias, dysproteinemias, e disorders do metabolism do glucose que compreendem administrando uma composição que compreende um composto do ether. Os compostos, as composições, e os métodos da invenção são também úteis para tratar e impedir a doença de Alzheimer, o syndrome X, proliferator peroxisome disorders receptor-relacionados ativados, septicemia, disorders thrombotic, obesity, pancreatitis, hypertension, a doença renal, o cancer, o inflammation, e o impotence. Em determinadas incorporações, os compostos, as composições, e os métodos da invenção são úteis na terapia da combinação com o outro therapeutics, tal como agentes hypocholesterolemic e hypoglycemic.