The present invention relates to a class of indolylquinone compounds that inhibit GRB-2 adaptor protein function, pharmaceutical compositions comprising these compounds, and methods for ameliorating the symptoms of cell proliferative disorders associated with GRB-2 adaptor protein function using these compounds. The present invention further relates to methods for treating insulin-related disorders, such as diabetes, insulin resistance, insulin deficiency and insulin allergy, and for ameliorating the symptoms of insulin-related disorders, using certain indolylquinone compounds and pharmaceutical compositions thereof. The present invention also relates to novel synthetic methods for the preparation of mono- and bis-indolylquinone compounds.

A invenção atual relaciona-se a uma classe dos compostos do indolylquinone que inibem a função da proteína do adaptador GRB-2, as composições pharmaceutical que compreendem estes compostos, e os métodos para melhorar os sintomas dos disorders proliferative da pilha associados com a função da proteína do adaptador GRB-2 usando estes compostos. A invenção atual mais adicional relaciona-se aos métodos para tratar disorders insulin-relacionados, tais como o diabetes, a resistência de insulin, a deficiência do insulin e o allergy do insulin, e para melhorar os sintomas de disorders insulin-relacionados, usando determinados compostos do indolylquinone e composições pharmaceutical disso. A invenção atual relaciona-se também aos métodos sintéticos da novela para a preparação de mono- e dos compostos bis-indolylquinone-indolylquinone.

 
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