The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and a compound of the general formula: ##STR1## which inhibits tumor cell growth. Methods of inhibiting targeted cell growth include contacting a target cell with a disclosed compound under conditions whereby the growth the target cell is inhibited, and methods for evaluating the growth inhibitory activity of the compounds include contacting a cell with an effective amount of the compound and measuring the CDK6 expression in the cell, wherein a reduction in CDK6 expression correlates with the growth inhibitory activity of the compound.

A invenção fornece os métodos e as composições que relacionam-se aos derivatives bioactive da novela de indole-3-carbinol (I3C), including os pharmaceuticals que compreendem um excipient pharmaceutically aceitável e um composto da fórmula geral: ## do ## STR1 qual inibe o crescimento da pilha do tumor. Os métodos de inibir o crescimento alvejado da pilha incluem contatar uma pilha do alvo com um composto divulgado sob circunstâncias por meio de que o crescimento a pilha do alvo é inibido, e os métodos para avaliar a atividade inhibitory do crescimento dos compostos incluem contatar uma pilha com uma quantidade eficaz do composto e a medição da expressão CDK6 na pilha, wherein uma redução na expressão CDK6 correlaciona com a atividade inhibitory do crescimento do composto.

 
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