The present invention relates to certain 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives that inhibit kinases, in particular VEGFR and/or PDGFR kinases. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.

La presente invenzione riguarda determinati derivati di 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone che inibiscono le chinasi, in particolare chinasi di PDGFR e/o di VEGFR. Le composizioni farmaceutiche che contengono questi residui, i metodi trattare le malattie mediate dalle chinasi che utilizzano le composizioni farmaceutiche che contengono questi residui ed i metodi la preparazione loro inoltre sono rilevate.

 
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