A therapeutic or preventive agent for pulmonary insufficiency, containing
as an active ingredient a diaminotrifluoromethylpyridine derivative
represented by the formula (I) or its salt:
##STR1##
wherein X is a --CW.sup.1 R.sup.1 group, a --COCOR.sup.2 group, a
--CW.sup.1 NHCOR.sup.2 group, a --C(.dbd.W.sup.1)W.sup.2 R.sup.3 group or
a --CW.sup.1 N(R.sup.4)R.sup.5 group; Y is an alkyl group, a --CW.sup.3
R.sup.6 group, a --COCOR.sup.7 group, a --NHCOR.sup.7 group, a
--C(.dbd.W.sup.3)W.sup.4 R.sup.8 group, a --(NH).sub.m SO.sub.2 R.sup.9
group, a --(NH).sub.m SO.sub.2 OR.sup.10 group or a --(NH).sub.m SO.sub.2
N(R.sup.11)R.sup.12 group; each of R.sup.1, R.sup.6 and R.sup.9 is a chain
hydrocarbon group, a monocyclic hydrocarbon group, a polycyclic
hydrocarbon group, a monocyclic heterocycle group or a polycyclic
heterocycle group; each of R.sup.2 and R.sup.7 is an alkyl group, an
alkoxy group, a phenyl group or a phenoxy group; each of R.sup.3, R.sup.8
and R.sup.10 is an alkyl group, an alkenyl group, an alkynyl group, a
cycloalkyl group, a phenyl group or a benzyl group; each of R.sup.4,
R.sup.5, R.sup.11 and R.sup.12 is an alkyl group; each of W.sup.1,
W.sup.2, W.sup.3 and W.sup.4 is an oxygen atom or a sulfur atom; and m is
0 or 1, is provided.
