A non-uniform memory access (NUMA) computer system includes a node interconnect to which a remote node and a home node are coupled. The home node contains a home system memory, and the remote node includes at least one processing unit and a cache. In response to the cache deallocating an unmodified cache line that corresponds to data resident in the home system memory, a cache controller of the cache issues a deallocate operation on a local interconnect of the remote node. In one embodiment, the deallocate operation is further transmitted to the home node via the node interconnect only in response to an indication, such as a combined response, that no other cache in the remote node caches the cache line. In response to receipt of the deallocate operation, a memory controller in the home node updates a local memory directory associated with the home system memory to indicate that the remote node does not hold a copy of the cache line.