The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step extraction process to be separated from the opioid agonist, the amount of opioid antagonist including being sufficient to counteract opioid effects if extracted together with the opioid agonist and administered parenterally.

A invenção relaciona-se na parte a um método de reduzir o potencial do abuso de um formulário de dosage oral de um analgesic do opioid, wherein uma quantidade analgesically eficaz de um agonist oral ativo do opioid é combinada com um antagonista do opioid em um formulário de dosage oral que requeira ao menos um processo two-step da extração ser separado do agonist do opioid, a quantidade de antagonista do opioid including ser suficiente neutralizar efeitos do opioid se extraído junto com o agonist do opioid e administrado parenterally.