Certain non-nucleoside compounds that will selectively inhibit telomerase by targeting the nucleic add structures, such as G-quadruplexes, that may be associated with human telomeres or telomerase have been identified. Inhibition of human telomerase by two perylenetetracarboxylic acid diimides and a carbocyanine has been demonstrated. .sup.1 H-NMR studies have evidenced the stabilization of a G-quadruplex by the perylenetetracarboxylic acid diimide compounds and provided evidence that these and structurally related compounds inhibit the telomerase enzyme by a mechanism consistent with interaction with G-quadruplex structures.

Se han identificado ciertos compuestos del no-non-nucleoside que inhibirán selectivamente telomerase apuntando el nucleic agregan las estructuras, tales como G-quadruplexes, que se puede asociar a los telomeres o a telomerase humanos. La inhibición del telomerase humano por dos diimides ácidos perylenetetracarboxylic y un carbocyanine se ha demostrado. los estudios del sup.1 H-NMR han evidenciado la estabilización de un G-g-quadruplex por los compuestos ácidos perylenetetracarboxylic del diimide y con tal que evidencia que éstos y los compuestos estructural relacionados inhiben la enzima del telomerase por un mecanismo constante con la interacción con las estructuras G-g-quadruplex.

 
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< Mammalian telomerase

< Diagnostic methods for conditions associated with elevated cellular levels of telomerase activity

> Antisense compositions for detecting and inhibiting telomerase reverse transcriptase

> Method for the detection of telomerase activity

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