A novel compound of the formula(I) having a high inhibitory activity against Grb2-Shc binding may be useful for the prevention and treatment of intracellular signal transmission-related diseases. ##STR1##

Um composto da novela do formula(I) que tem uma atividade inhibitory elevada de encontro ao emperramento de Grb2-Shc pode ser útil para a prevenção e o tratamento de doenças transmissão-relacionadas do sinal intracellular. ## do ## STR1
 
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< Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use

< Permanent amniocytic cell line, its production and use for the production of gene transfer vectors

> Methods for identifying compounds for inhibiting of neoplastic lesions, and pharmaceutical compositions containing such compounds

> Biopolymer marker indicative of disease state having a molecular weight of 1465 daltons
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