Compounds of the formula: ##STR1## where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

Samenstellingen van de formule: ## STR1 ## waar de formulevariabelen zoals die in de onthulling worden bepaald zijn, rem of blokkeer voordelig de biologische activiteit van de picornaviral 3C protease. Deze samenstellingen, evenals farmaceutische samenstellingen die deze samenstellingen bevatten, zijn nuttig om besmette patiënten of gastheren met één of meerdere picornaviruses, zoals RVP te behandelen. De tussenpersonen en de synthetische methodes om dergelijke samenstellingen worden voor te bereiden ook beschreven.

 
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