Compositions and methods are provided for treating diseases associated with abnormal cell proliferation such as cancer by storing inherent tumor-suppressing functions of neoplastic cells through DNA hypomethylation. The method comprises: delivering to a patient suffering from cancer a therapeutically effective amount of a DNA methylation inhibitor such as decitabine, in combination with an effective amount of an anti-neoplastic agent whose activity as an anti-neoplastic agent in vivo is adversely affected by aberrant DNA methylation. The anti-neoplastic agent can be an alkylating agent, an antibiotic agent, an antimetabolic agent, a retinoid, a hormonal agent, a plant-derived agent, an anti-angiogenesis agent and a biologic agent such as monoclonal antibody and interferon.

Las composiciones y los métodos se proporcionan para las enfermedades que tratan asociadas a la proliferación anormal de la célula tal como cáncer almacenando funciones tumor-que suprimen inherentes de células neoplásticas con el hypomethylation de la DNA. El método abarca: entregando a un paciente que sufre de cáncer a la cantidad terapéutico eficaz de un inhibidor del methylation de la DNA tal como decitabine, conjuntamente con una cantidad eficaz de un agente antineoplástico que actividad como agente antineoplástico in vivo es afectada al contrario por el methylation aberrante de la DNA. El agente antineoplástico puede ser un agente alkylating, un agente antibiótico, un agente antimetabolic, un retinoid, un agente hormonal, un agente planta-derivado, un agente del anti-angiogenesis y un agente biológico tal como anticuerpo e interferón monoclonal.

 
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