Advanced glycation endproducts (AGEs) have been implicated in the pathogenesis of a variety of debilitating diseases such as diabetes, atherosclerosis, Alzheimer's and rheumatoid arthritis, as well as in the normal aging process. Five compounds are here reported to be active in breaking AGE-protein cross-links. These compounds are L-bis-[4-(4-chlorobenzamido-phenoxyisobutyryl)cystine] (LR20); 4-(3,5-dichlorophenylureido)phenoxyisobutyryl-1-amido-cyclohexane-1-carbox ylic acid (LR23); methylene bis [4,4'-(2-chlorophenylureido-phenoxyisobutyric acid)] (LR90); 5-arninosalicylic acid (5-ASA); and metformin. These compounds may be used to reverse the debilitating effects of those diseases in which AGEs are formed.

Os endproducts avançados do glycation (idades) foram implicados no pathogenesis de uma variedade de doenças debilitating tais como o diabetes, o atherosclerosis, o Alzheimer e o arthritis rheumatoid, assim como no processo normal do envelhecimento. Cinco compostos são relatados aqui para ser ativos em quebrar ligações transversais da Idade-proteína. Estes compostos são L-bis-[4-(4-chlorobenzamido-phenoxyisobutyryl)cystine ] (LR20); 4-(3,5-dichlorophenylureido)phenoxyisobutyryl-1-amido-cyclohexane-1-carbox ácido ylic (LR23); bis do metileno [ ácido 4,4'-(2-chlorophenylureido-phenoxyisobutyric) ] (LR90); ácido 5-arninosalicylic (5-ASA); e metformin. Estes compostos podem ser usados inverter os efeitos debilitating daquelas doenças em que as idades são dadas forma.

 
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