A wearable, self contained drug infusion device is disclosed that is
capable of achieving the precise flow rate control needed for
dose-critical drugs such as insulin. In preferred embodiments of the
device, piezoelectrically-actuated valve or pump structures are used in
combination with thermal flow sensors and closed-loop control circuits for
providing the desired flow rate control. The device has a two-part
construction in which the more expensive electronic components are housed
in a reusable portion and the fluid delivery components are housed in a
separable disposable portion. The invention may also utilize a wireless
unit for controlling the operation of the drug infusion device.