The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives of andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of andrographolide have the general formula (I). ##STR1##

La présente invention concerne les agents anticancéreux de roman, leurs stéréoisomères, leurs polymorphes, leurs sels pharmaceutiquement acceptables, et leurs solvates pharmaceutiquement acceptables. La présente invention se relie plus en particulier aux dérivés de roman de l'andrographolide, de leurs stéréoisomères, de leurs polymorphes, de leurs sels pharmaceutiquement acceptables, et de leurs solvates pharmaceutiquement acceptables. Les dérivés de roman de l'andrographolide ont la formule générale (i). ## du ## STR1

 
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