Compounds of formulae (IA) and (IB): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, Ar.sup.1 and X are as defined above, are endothelin antagonists. The compounds are therefore useful in the treatment of a variety of conditions mediated by endothelin, such as restenosis, renal failure and systemic and pulmonary hypertension.

Смеси формул (IA) и (IB): ## ## STR1 при котором R.sup.1, R.sup.2, R.sup.3, Ar.sup.1 и х как определено выше, антагонисты endothelin. Смеси поэтому полезны в обработке разнообразия условий посредничанных endothelin, such as restenosis, ренальным отказом и внутрирастительной и легочной гипертензией.

 
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