A dentifrice closure on a dentifrice tube can emit a signal upon the opening of the closure to dispense some of the dentifrice. The closure is comprised of a base portion to attach the closure to the dentifrice tube and a lid portion that closes the dispensing opening of the dentifrice tube and which contains switch timer and signal generator. The signal generator can be a light, but preferably is a sound generator, and most preferably a music generator. Upon the lid being opened, a switch activates the timer which in turn activates the signal generator. Regardless of the position of the switch after a lid opening (the lid can be quickly closed) the signal will be emitted for a set period of time.

 
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> NRAGE nucleic acids and polypeptides and uses thereof

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