A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted azetidine, pyrrolidine or piperidine ring are selective antagonists of the human 5-HT.sub.2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and depression.

Uma classe do anel dos derivatives wherein o moiety do sulphonyl é unido também a um azetidine N-arylalkyl-substituído, do pyrrolidine ou do piperidine do phenylsulphonyl é antagonistas seletivos do receptor 5-HT.sub.2A humano e é conseqüentemente útil como agentes pharmaceutical, especial no tratamento e/ou na prevenção de condições adversas do sistema nervoso central, including a esquizofrenia e o depression.