A method for promoting autogenous ingrowth of damaged or diseased tissue selected from a group consisting of ligaments, tendons, muscle and cartilage, the method comprising a step of surgically repairing the damaged or diseased tissue by attachment of a tissue graft, wherein the tissue graft is formed from a segment of connective tissue protein after an acellularization process, the segment being crosslinked with genipin, its analog or derivatives. The genipin-fixed acellular tissue provides a microenvironment for tissue regeneration adapted for use as a biological implant device due to its low cytotoxicity.

Un método para promover el ingrowth autógeno del tejido fino dañado o enfermo seleccionado de los ligamentos de un grupo, de los tendones, del músculo y del cartílago que consisten en, el método que abarca un paso quirúrgico de reparar el tejido fino dañado o enfermo por el accesorio de un injerto del tejido fino, en donde el injerto del tejido fino se forma de un segmento de la proteína del tejido fino conectivo después de un proceso del acellularization, el segmento que es reticulado con el genipin, su análogo o los derivados. El tejido fino acellular genipin-fijo proporciona un microambiente para la regeneración del tejido fino adaptada para el uso como dispositivo biológico del implante debido a su citotoxicidad baja.

 
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