The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.

A invenção inclui os antibodies que fornecem a atividade superior do anticoagulante ligando o ser humano nativo TF com a afinidade e o specificity elevados. Os antibodies da invenção podem eficazmente inibir o coagulation de sangue em vivo. Os antibodies da invenção podem ligar o ser humano nativo TF, sozinho ou atual em um TF:VIIa complexo, eficazmente impedindo o fator X que ligam ao TF ou nesse complexo, e reduzindo desse modo o coagulation de sangue. Os antibodies preferidos da invenção ligam especificamente um epitope do conformational predominant ao ser humano nativo TF, que o epitope fornece um local obrigatório do antibody inesperada forte.

 
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