A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

Um polypeptide hMutT2 e um DNA humanos (RNA) que codificam tal polypeptide e um procedimento para produzir tal polypeptide por técnicas recombinant são divulgados. São divulgados também os métodos para utilizar tal polypeptide para hydrolyzing e eliminar nucleotides oxidados do guanine do pool do nucleotide para assegurar a síntese correta do DNA. Os assays diagnósticos são divulgados também quais detectam a presença de um formulário mutated de hMutT2 e da sobre-expressão da proteína hMutT2.
 
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