The present invention relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, n, p, W, X, Y and Z are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats, horses and livestock.

La presente invenzione riguarda i residui del ## del ## STR1 di formula in cui R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, il N, la p, il W, la X, Y e la Z sono definiti come nella specifica, alle composizioni farmaceutiche che le contengono ed al loro uso medicinale. I residui dell'invenzione sono utili nel trattamento o nell'alleviamento di infiammazione e di altri disordini associati infiammazione, quali l'artrite, il cancro di due punti e la malattia del Alzheimer in mammiferi, preferibilmente in esseri umani, in cani, in gatti, in cavalli ed in bestiame.

 
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