A protein preparation that mediates Ca.sup.+2 transbilayer movement of phospholipid is disclosed. Additionally, a modified or mutated protein preparation, wherein the protein has a reduced ability to mediate transbilayer movement, is disclosed. In a preferred form of the invention, the protein has been modified such that post-translational modification can no longer occur.

Se divulga una preparación de la proteína que media el movimiento del transbilayer Ca.sup.+2 del phospholipid. Además, se divulga una preparación modificada o transformada de la proteína, en donde la proteína tiene una capacidad reducida de mediar el movimiento del transbilayer. En una forma preferida de la invención, la proteína se ha modificado tales que ocurre la modificación poste-de translacio'n puede no más de largo.

 
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