This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury.

Deze uitvinding wordt geleid aan nieuwe (N-substituted) van indoolijs/ced-3-inhibitor samenstellingen. De uitvinding wordt ook geleid aan farmaceutische samenstellingen van dergelijke indoolsamenstellingen, plus het gebruik van dergelijke samenstellingen in de behandeling van patiënten die aan ontstekings, auto-immune en neurodegenerative ziekten, voor de preventie van ischemische verwonding lijden.
 
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< Inhibition of apoptosis using interleukin-1.beta.-converting enzyme (ICE)/CED-3 family inhibitors

< Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use

> C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases

> Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
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