The invention relates to the human protein FRAP, and in particular to the FKBP12-rapamycin binding domain thereof and to the ternary complex formed by the FRB domain, rapamycin and FKBP12. A new crystalline composition comprising the ternary complex, coordinates defining its three dimensional structure in atomic detail, and uses thereof are disclosed.

Вымысел относит к людскому протеину FRAP, и в частности к домену FKBP12-rapamycin binding thereof и к троичному комплексу сформированному доменом, rapamycin и FKBP12 FRB. Показаны новый кристаллический состав состоя из троичного комплекса, координаты определяя свою габаритную структуру 3 в атомной детали, и пользы thereof.

 
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